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Royalties were , 491, 000 in 2002 as compared with , 663, 000 in 2001, an increase of approximately 89%. The increase in 2002 as compared with 2001 is due in part to an increase in royalties earned on sales of ALLEGRA. The royalties earned on ALLEGRA sales were , 504, 000 in 2002 as compared to , 254, 000 in 2001, an increase of approximately 40%. The increase also reflected royalties earned on sales of CLARINEX of , 370, 000 in 2002 as compared to ##TEXT## in 2001, under the DCL Agreement. Sepracor began earning royalties on commercial sales of ALLEGRA in the United States during February 2001, in Japan during November 2000 and in several other countries from 1999 to the present. The Company began earning royalties on commercial sales of CLARINEX, which are primarily in the United States, in January 2002. License fees and other revenues were 0, 000 in 2002 as compared with , 184, 000 in 2001. Other revenues in 2002 represent Sepracor's reimbursement of training costs under the ASTELIN Agreement and in 2001 represent revenues of BioSphere other than product revenues recognized by BioSphere through July 2, 2001 in connection with its core EmboSphere Microsphere business. Cost of products sold was , 369, 000 in 2002 as compared with , 411, 000 in 2001, an increase of approximately 52%. The increase was due to product sales also increasing by 52%. Cost of product sales as a percentage of product sales remained at 12% in 2002 as it was in 2001. Cost of royalties earned was approximately 0, 000 in 2002 as compared to ##TEXT## in 2001. The cost in 2002 relates to an obligation to a third party as a result of royalties earned by Sepracor under the DCL Agreement on sales of CLARINEX, which the Company began earning in 2002. Cost of license fees and other revenues was 0, 000 in 2002 as compared with 3, 000 in 2001. The 2002 cost relates to the cost for training relating to the ASTELIN Agreement and in 2001 relates to the cost of BioSphere revenues other than those related to its core EmboSphere Microsphere business. Research and development expenses were 3, 797, 000 in 2002 as compared with 1, 278, 000 in 2001, an increase of approximately 5%. The increase in 2002 as compared with 2001 is primarily due to increased spending on preclinical and clinical studies in Sepracor's pharmaceutical programs, including 1 ; the continuation of phase III clinical study costs relating to XOPENEX MDI, 2 ; the initiation of new clinical studies for SOLTARA brand tecastemizole, and 3 ; the initiation of Phase III clinical studies for R, R ; -formoterol. In 2002 significant investments were also made in the initiation of Phase III clinical studies for S ; -oxybutynin and in NDA preparation costs and Phase III clinical study costs relating to ESTORRA brand eszopiclone. Drug development and approval in the United States is a multistep process regulated by the FDA. The process begins with the filing of an Investigational New Drug Application "IND" ; , which, if successful, allows opportunity for clinical study of the potential new drug. Clinical development typically involves three phases of study: Phase I, II and III. The most significant costs in clinical development are in the Phase III clinical trials.
Sanford A week or two after that encounter, I came down with the strangest flu. It had the usual aches and respiratory symptoms, but also a high fever and a rash. It lasted for a couple of weeks at Christmas when my partner, Lewis, and I were in Denver visiting my mother, just two weeks before she died. I have since learned that when people become infected with the human immunodeficiency virus, they often have such an illness. It was on this visit that my mother asked us over dinner one night whether we had seen a TV documentary about "the disease a lot of people in New York are getting." "Homosexual" was a word I never heard from my mother, and I didn't utter it around her. Sex wasn't anything we talked about. I had been living with the same man for more than 14 years, and my mother, who was perfectly accepting of our relationship -- a marriage in every sense but the legal one -- was still hoping for grandchildren from her only child. Yes, we told her, we had seen the program. End of discussion. I didn't volunteer that I thought I myself might have recently been infected. My New Year's resolution was to become as chaste as a priest is supposed to be, and I did. I was determined not to get infected if I wasn't already, and I didn't want to infect anybody else. But the signs were there. I tired easily. On a trip to Japan in 1984, I had the first of recurring night sweats, which can be a sign of infection. When I dieted, I would drop weight quickly -- 48 pounds in one four-month period. When the HIV blood test finally became available in 1985, I wasn't interested in opening Pandora's Box. There wasn't anything you could do for HIV then anyway. It wasn't until 1989 that researchers reported that HIV-positive people -- and not just patients with full-blown AIDS -- might benefit from the drug AZT. Now there was a good reason to be tested. I got the news on Sept. 22, 1989, when a woman named Bea at the New York City public-health clinic on Ninth. Far be it for a gentleman, such as i am, to make social and verbal blunders by assuming a woman is with child when she may very well be struggling with a little extra weight in the tummy.
CSB 2.09 Additions to schedules IV and I. 1 ; ADDITION OF BENZODIAZEPINE SUBSTANCES TO SCHEDULE IV. Paragraphs cm ; , cn ; , cp ; , and hm ; of sub. 2 ; , s. 161.20, Stats., schedule IV are hereby created to read: cm ; Chlordiazepoxide cn ; Clonazepam cp ; Chlorazepate cr ; Diazepam em ; Flurazepam hm ; Oxazepam 2 ; ADDITION OF THE THIOPHENE ANALOG OF PHENCYCLIDINE TO SCHEDULE I. Paragraph u ; of sub. 4 ; , s. 161.14, Stats., schedule I is hereby created to read: u ; Thiophene analog of phencyclidine 3 ; ADDITION OF MECLOQUALONE TO SCHEDULE I. Subsection 5 ; and par. a ; of s. 161.14, Stats., schedule I are hereby created to read: 5 ; Depressants. Unless specifically excepted or unless listed in another schedule, any material compound, mixture or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers and salts of isomers is possible within the specific chemical designation: a ; Mecloqualone 4 ; ADDITION OF DIFENOXIN TO SCHEDULE I. Paragraph hg ; of sub. 2 ; , s. 161.14, Stats., schedule I is hereby created to read: hg ; Difenoxin 5 ; ADDITION OF 2, 5 DIMETHOXYAMPHETAMINE, 4-ROMO-2, 5 v ; , w ; and x ; of sub. 4 ; , s. 161.14, Stats., schedule I are hereby created to read: v ; 2, 5-dimethoxyamphetamine w ; 4-bromo-2, 5-dimethoxyamphetamine x ; 4-methoxyamphetamine. Pathway of Tau Aggregation Into Alzheimer Paired Helical Filaments E. Mandelkow, M. von Bergen, A. Schneider, S. Barghorn, J. Biernat, E.-M. Mandelkow.

Stuffy noses can be managed with either decongestants such as pseudoephedrine Sudafed is one brand name ; or prescription nasal steroids. such as Rhinocort, Flonase, and Nasocort. DID YOU KNOW? Some of these are safe for children as young as three years of age. Claritin, one of the non-sedating antihistamines, is now available over the counter--no Itchy and runny noses can be managed by antiprescription is needed. In general this medi- histamines such as those described previously. cine is now LESS expensive than the coThe most important thing you can do when you payment for Allegra, Zyrtec, and Clarinrx a have allergies is to AVOID the offending allergen. Allergens are proteins that cause your medicine very similar to Claritin ; . body to release histamine. Histamine makes CVS has already formulated a generic brand the tissues in your respiratory system swell and of Loratidine Claritin ; which is even less $ drip stuffy nose, runny nose and eyes ; . If you than the generic form of Claritin. have allergies to dogs or cats, avoid them. If you are allergic to dust or dust mites, mold and Alavert, a new once a day antihistamine, is mildew ask your provider for specific instrucalso available over the counter. It is a tablet tions for avoiding these allergens. that dissolves on the tongue. You don't have to treat allergy symptoms with Check these out as they will save you money anything. But if your symptoms interfere with in the long run. If you feel that the other your life these medicines can be very helpful. prescription antihistamines are the only medicines that work for you, then by all means, continue to use them. ITCHY EYES Pollens and other allergens can cause eyes to itch and tear. Try and stay indoors when the pollen counts are high. If you or your child must be outside at those peak times, rinse the eyes with an eye wash that can be purchased at the pharmacy when you come and periactin. Cents or less per tablet. It makes sense for consumers and health insurance companies ; to prefer the over-the-counter medications when equivalent prescription medications such as Allegra, Clar9nex and Zyrtec range in price from .90 to .75 per dose. Prilosec OTC sells for approximately per capsule. As a prescription medication, it sells for an average of .60 per capsule 20 mg ; and .62 per capsule 40 mg ; . The generic version of Prilosec omeprazole ; costs approximately .50 per capsule. Again, it makes sense for consumers to purchase Prilosec OTC at their local store. It's important to be an educated consumer. Remind your clients to ask for generics when they are available and to watch for when their prescription medications will be available as over-the-counter medications. By making informed decisions, your clients will save money now . and in the long run, when it comes to their health insurance.

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Table 2. Workload intensities for the two-stage submaximal trial menstrual phase comparison and entocort.

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1. Walton 1992 946 visits resulted in an incidence of 3.17% flare-ups. Flare-ups increased to 19% with severe presenting symptoms, 7% with pulp necrosis, and 5% with acute apical periodontitis. Imura 1995 Factors associated with flare-ups: multiple appt., retreatment, periradicular pain prior to treatment, presence of radiolucent lesions, and patients taking analgesics. Study reported an incidence of 1.58% from 1012 teeth. Tronstad 1979 Study reported 91% success from RCT and NO decrease in success if flare-up occurs. Baumgartner, Svec et al 1983 Risk factor for post obturation pain was extrusion of sealer or gutta-percha. No relationship with vitality, apical lucency, root # or level of obturation. Pain rate w in first 24 hrs. 47.6% 14% severe and singulair. In this procedure, the woman may receive intravenous fluid and an analgesic or sedative. Validity and reliability of adult recall of past sun exposure in a case-control study of multiple sclerosis and lexapro. There is an adequate vocabulary for depression, similar terminology is required for other CNS disorders. For example, schizophrenia is chronic.
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Coverage of Non-Sedating Antihistamines Brand non-sedating antihistamine drugs are paid as Tier 3, regardless of the drug's formulary status of preferred or non-preferred drug. For example, if you prefer to take the medication Clarinec rather than buying Claritin over the counter, you will pay the Tier 3 copayment. Retail Refill Limit The Prescription Drug Program will maintain a Retail Refill Limit policy. The retail refill limit requires that you use the mail-order pharmacy if you are prescribed a maintenance medication, rather than refilling multiple prescriptions for the same drug at a retail pharmacy. If you or a covered dependent receives a prescription for a maintenance medication and you do not use the mailorder pharmacy, your prescriptions may not be covered. In some circumstances, you may not be required to use the mail-order pharmacy. For example, there are several categories of medications that are uniquely appropriate for multiple refills at your local pharmacy and are therefore exempt from the mandatory mail-order provision, as outlined above ; . If you have a prescription for any of the following medications, the Prescription Drug Program allows you to receive multiple refills at your local retail pharmacy: Anti-infectives, including antibiotics Amoxicillin, Biaxin ; , antivirals Zovirax, Famvir ; , antifungals Diflucan ; , and drops used in the eyes and ears Polsporin Opth, Cipro Otic ; . Please note that drops must be prescribed specifically to treat infection. For example, glaucoma drops are not covered. Prescription cough medications, including Phenergan with Codeine, Tessalon, and Tussionex. 25. Greyhounds can suffer from muscle cramps. This condition is more common in and zoloft and Clarinex online!
Listed below is a list of common antihistamines: Some store brands are not listed. Please check the ingredients on the package or ask your pharmacist: All lower case is the generic drug. Actifed Allegra, Allegra D Allerx Atarax Atrohist azatadine Benadryl Bromphed brompheniramine carbinoxamine cetirizine chlorpheniramine ChlorTrimeton Clarinex, Clarinx D Claritin, Claritin D clemastine CoTylenol cyproheptadine desloratadine Dimetane Dimetapp Diphenhydramine Dristan fexofenadine hydroxyzine loratadine Nolamine Optimine PBZ Periactin Rondec Semprex D Tavist, Tavist D Teldrin Trinalin tripelennamine triprolidine Tylenol Unidecon Vistaril Zyrtec, Zyrtec D.

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Building upon its 50-year history as a leader in developing therapies for allergy and asthma, Schering-Plough is pursuing new and more effective therapies to prevent or block the body's allergic and immunological responses. In December 2000, the Company submitted marketing applications to the FDA for three new CLARINEX formulations: a fixed combination of desloratadine and the decongestant pseudoephedrine sulfate as a twice-daily treatment of SAR in adults and children 12 years of age and older; a syrup form for the treatment of SAR and CIU in patients as young as 2 years of age; and a rapidly disintegrating tablet formulation. A U.S. regulatory application is also pending for CLARINEX in treating CIU. EU applications for treating CIU and for the syrup form were filed in January 2001. Phase II and Phase III studies for various line extensions are ongoing and compazine.
After delays caused by production problems at manufacturing plants, Clarinex desloratadine ; was finally approved in December 2001. The advantages of Clarinex over its predecessor, Claritin, are not well defined. Table 3. Effect of tocopherol and pure flavonoids on H2O2 induced expression of VEGF.

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Alzheimer’ s illness narratives are often acts of memorial reconstruction, attempts to retrieve and to salvage lost personal and familial histories in the face of their erosion in the mind of the individual with the disease. Estrogen overstimulates the tissue lining the uterus the endometrium ; and causes uncontrolled cell growth, a condition known as hyperplasia , which is a strong risk factor for cancer. Sarcoptic mange caused by Sarcoptes scabiei var. wombati currently occurs throughout the range of the common wombat Vombatus ursinus ; in southeast Australia and has the potential both to dramatically reduce the local abundance of wombats and threaten the survival of small isolated populations Martin et al., 1998 ; . However there has been little investigation of sarcoptic mange in wombats and the application of knowledge of S. scabiei in humans and other animals to this unique fossorial marsupial herbivore may be inappropriate Skerratt et al., 1998 ; . The histopathologic changes in skin and internal organs of common wombats with severe parakeratotic sarcoptic mange have been investigated Skerratt, 1998 ; . The lesions in affected wombat skin are similar to those found in other animals and humans except for the consistently mild inflammatory infiltrate seen in the dermis of wombats compared with the variable re179 and buy periactin.
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Specific manner, your love for Him will grow. Even in the present days, there are devotees who love the Lord intensely. There was a school teacher who thought of himself as Dasaratha in relation to Lord Rama. He used to do puja at home every day with a lot of love. One day, he had to go out on some important work. So, he told his daughter-in-law to do the puja. On return, he went straight to the puja room. One look at the Lord and he fell down on the ground gripped with severe stomach pain. On questioning the daughter-in-law, it was found that she had done the puja all right, but the rice offered to the Lord was not fully cooked. Such was the devotee's tuning with the Lord that he felt the pain physically. So, develop a bonding with the Lord. Don't ask me what the relationship should be. It depends on your temperament, your bent of mind and your emotional needs.
The associated photooxidative stress results in the formation of dna mutations including c-t transitions and transversions, as well as the induction of matrix metalloproteinases and p53 mutations. ALLEGRA ALLEGRA-D ASTELIN ATARAX 100 mg brompheniramine pseudoephedrine 4 mg 45 mg per 5 ml brompheniramine pseudoephedrine ext-rel 12 mg 120 mg brompheniramine pseudoephedrine ext-rel 6 mg 60 mg carbinoxamine pseudoephedrine 1 mg 15 mg per ml chlorpheniramine pseudoephedrine ext-rel 8 mg 120 mg CLARINEX clemastine 2.68 mg cyproheptadine CYPROHEPTADINE syrup While all generics may not be listed, most generics are covered as Tier 1. Tier Tier Tier Tier Tier 2 3 2.

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We present five levels in the relation between sex and relationship: the individual sex problem of partner a always influences partner b 'becomes relational' ; the relationship reinforces a sex problem that existed before the relationship is the cause of the sex problem the relationship 'needs' the sex problem the relationship boycotts the solution of the sex problem.
ABILIFY ACCOLATE ACCU-CHEK monitors ACCU-CHEK strips ACEON acetaminophen w codeine acetaminophen w hydrocodone ACIPHEX ACTIVELLA ACTONEL ACTONEL + CALCIUM ACTOPLUS MET ACTOS ACULAR, -LS, -PF acyclovir oral forms ; ADDERALL XR ADVAIR DISKUS ADVICOR AEROBID, -M AGGRENOX ALAMAST albuterol all forms ; alclometasone ALDARA ALLEGRA-D allopurinol ALOCRIL ALOMIDE ALORA ALPHAGAN P alprazolam ALREX ALTABAX oint ALTACE ALTOPREV amantadine hcl AMBIEN CR amcinonide AMERGE amiloride hcl w hctz amiodarone hcl amitriptyline hcl amlodipine besylate amlodipine benazepril amox potassium clavulanate amoxicillin amphetamine salt combo ANALPRAM-HC ANDRODERM ANDROGEL ANTARA ANZEMET APIDRA apri Tier G generic product PAR Prior Authorization Required ST Step Therapy 5.8 15.1.4 18.1 aranelle ARANESP ARICEPT ARIMIDEX ARIXTRA ARTHROTEC ASACOL ASCENSIA ASTELIN ATACAND ATACAND HCT atenolol & w chlorthalidone ATROVENT AUGMENTIN XR AVANDAMET AVANDARYL AVANDIA AVAPRO AVALIDE AVELOX aviane AVINZA AVITA AVODART AVONEX, -ADMINISTRATION PACK AXERT AZASITE azathioprine AZELEX azithromycin AZMACORT AZOPT baclofen BACTROBAN cream balziva BARACLUDE B-D testing strips BECONASE AQ benazepril benazepril hctz BENICAR BENICAR HCT BENZACLIN benzonatate benztropine mesylate betamethasone dipropionate betamethasone dp augmented BETASERON BETIMOL bisoprolol bisoprolol w hctz BONIVA brimonidine tartrate bromocriptine mesylate BROVANA bumetanide bupropion, -sr, -xl 300mg buspirone hcl Tier P Preferred Brand Product QL Quantity Level Limit 13.7 10.2.2 5.9.3 butalbital compound butalbital acetaminophen caffeine butorphanol nasal spray BYETTA CADUET calcitonin nasal spray calcitriol camila CANASA captopril captopril hctz carbamazepine CARBATROL carbidopa levodopa CARDENE SR CARDIZEM LA carisoprodol carvedilol CASODEX CATAPRES-TTS CAVERJECT CEDAX cefaclor, cefaclor-er cefadroxil cefdinir cefpodoxime cefprozil CEFTIN SUSP ; cefuroxime tab ; CELEBREX CELLCEPT CENESTIN cephalexin cesia CHEMSTRIP BG chlorthalidone chol sal magnesium salycylate CIALIS ciclopirox cilostazol cimetidine CIPRO HC CIPRODEX OTIC ciprofloxacin hcl ophth drops ; ciprofloxacin hcl er citalopram CLARINEX CLARINEX-D 24 HOUR clarithromycin XL CLIMARA CLIMARA PRO clindamycin hcl clindamycin phosphate clobetasol 5.1.2 5.1.1.

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Before considering a brand-name antihistamine for your Blue Care Network members who suffer from hay fever or allergies, please first prescribe over-the-counter Claritin Alavert g ; . A trial with Claritin Alavert loratadine ; is required prior to coverage of Allegra, BCN's only brand-name non-sedating antihistamine. Zyrtec and Clarinex are nonformulary and aren't covered for most BCN members. But a dose of hydroxyzine Atarax Vistaril ; in the evening yields a therapeutic concentration of Zyrtec cetirizine ; the following morning. Over-the-counter Claritin Alavert loratadine ; 10mg is exactly the same as the original prescription-only version. Some members may have the notion that since it's now available over-the-counter, that somehow it's less effective than prescription-only alternatives. Please assure your patients that the over-the-counter version is identical to the original, but is just a fraction of the cost. You might also consider using the generic name loratadine 10mg ; for your members who are reluctant to consider an over-the-counter product. Please prescribe Claritin Alavert loratadine 10mg ; for your BCN members who require treatment with a non-sedating antihistamine! Emily M. Du Vall Pharm.D., is a Pharmacy Services Manager at Blue Care Network. Please contact her for further information. ODJFS Quantity Limits Number of units per day Effective November 29, 2006 Drug Actonel Advair Diskus Advair Diskus Advair Diskus Allegra Allegra Allegra Allegra-D Ambien Ambien Ambien CR Ambien CR Aricept Aricept Clarinex Clarinex Reditab Concerta Concerta Coreg Coreg Coreg Coreg Cozaar Cozaar Cozaar Crestor Crestor Crestor Crestor Detrol Detrol Detrol LA Detrol LA Diovan Diovan Diovan Diovan Diovan HCT Diovan HCT Diovan HCT Diovan HCT Diovan HCT Ditropan XL Ditropan XL Ditropan XL Effexor XR Effexor XR Effexor XR Flovent Generic Name Risedronate Sodium Fluticasone Salmeterol Fluticasone Salmeterol Fluticasone Salmeterol Fexofenadine HCl Fexofenadine HCl Fexofenadine HCl Fexof Pseud Zolpidem Tartrate Zolpidem Tartrate Zolpidem Tartrate Zolpidem Tartrate Donepezil Donepezil Desloratadine Desloratadine Methylphenidate Methylphenidate Carvedilol Carvedilol Carvedilol Carvedilol Losartan Losartan Losartan Rosuvastatin Rosuvastatin Rosuvastatin Rosuvastatin Tolterodine Tart. Tolterodine Tart. Tolterodine Tart. Tolterodine Tart. Valsartan Valsartan Valsartan Valsartan Valsartan-HCTZ Valsartan-HCTZ Valsartan-HCTZ Valsartan-HCTZ Valsartan-HCTZ Oxybutynin Cl Oxybutynin Cl Oxybutynin Cl Venlafaxine ER Venlafaxine ER Venlafaxine ER Fluticasone Strength Qty Day 35mg 0.143 50-100.

He recommended a much higher dosage, but that would have made users sleepy. The company also could have sought approval for more than one dose level, but 10 milligrams was the only one that it thought struck the right balance between efficacy and sedation. This dose is "safe and effective and without sedating effects, " ScheringPlough says, seeing "no clinical need for an alternate dose." Claritin finally won approval in 1993 at that dose. It soon became the biggest-selling antihistamine in the world after safety concerns knocked off Seldane and another drug. In 1997, the FDA made it easier to pitch drugs directly to consumers. It said an abbreviated list of side effects would be sufficient in consumer ads. More than any other drug maker, Schering-Plough jumped at this opportunity, revolutionizing pharmaceutical marketing in the process. "Schering-Plough had tremendous insight They are the ones who started aggressive direct-to-consumer advertising, " says Anne DeVereux, president of ad agency Merkley Newman Harty Healthworks. The Claritin ads -- colorful and ubiquitous -- pushed allergy sufferers to ask their doctors for the pill. TV viewers plagued by pollen saw handsome folks frolicking outdoors accompanied by Irving Berlin's "Blue Skies." Dr. Straus contends that by reinforcing people's belief that the drug worked, the ads in fact contributed to Claritin's chief benefit -- a placebo effect. Asked about such an effect, Schering-Plough says "no amount of marketing can sustain a drug that is not effective." It notes that "regulatory authorities world-wide have approved Claritin 10 mg. as safe and effective." Meanwhile, to prepare for the day Claritin's patent expired, Schering-Plough poured more money into its labs. It increased research spending 17% in 1997, 19% in 1998 and 18% in 1999. But drug research is famously difficult, and in their search for a follow-on Claritin product, the labs largely came up dry. So Schering-Plough turned to one of the products that Claritin converts to in the body after it is swallowed. The one that inhibits allergy symptoms is called desloratadine. Schering-Plough decided to use this as the basis of its successor drug. That meant the successor, called Clarinex, would be essentially the same as Claritin -- not an ideal situation when it came time to promote it over Claritin. Moreover, Clarinex's sales exclusivity would probably extend only through mid-2007. Although it's possible that patents on use or formulation of the medicine would extend this, the company could be mounting a huge and costly promotion for a drug destined to face generic competition of its own in a few years. Manufacturing Problems Schering-Plough applied in October 1999 for permission to sell this successor drug, expecting approval within a year. But its relations with the FDA frayed seriously, delaying approval. FDA inspectors determined that the company's manufacturing plants in New Jersey and Puerto Rico weren't following proper procedures. Among the most worrisome findings: Schering-Plough was sometimes shipping asthma inhalers -- a critical aid for asthmatics -without any medicine inside. For years, Schering-Plough recalled suspect asthma inhalers; for years, the FDA warned the company to clean up its act; for years, executives promised reforms. In January 2000, a top executive said Schering-Plough had resolved all the FDA's manufacturing issues. It hadn't. More than a year later, the company disclosed that regulators were refusing to approve Clarinex until it fixed its manufacturing problems. The company promised to hire hundreds of quality-control employees and spend millions in manufacturing improvements. Three months ago, it simultaneously announced two things: The FDA was levying a fine over the manufacturing mishaps, which still hasn't been determined but might be as much as 0 million; and Clarinex at last had marketing approval. Sales began in January. The delay left the company less than a year to persuade its legions of Claritin users to start using Clarinex instead. Drug companies usually need years to switch loyal users of a drug over to a follow-on product. When Bristol-Myers Squibb Co.'s Glucophage diabetes medicine faced generic com petition, the maker had 15 months to try to switch patients to two successor versions. Even though these were more convenient, it managed to convert only about a third of the patients. Switching Markets The other blow to Schering-Plough's allergy franchise was totally unexpected. An FDA advisory committee began considering whether to switch Claritin and similar nonsedating antihistamines, such as Aventis SA's Allegra and Pfizer Inc.'s Zyrtec, to nonprescription status. Such switches normally result from requests by the drugs' makers. In this case, the makers were staunchly opposed to the switch. The impetus came from a managed-care group, Wellpoint Health Networks, which is out to curb the cost of treating allergies. Schering-Plough fought the move at a hearing last May, contending that changing Claritin to over-the-counter status could create a "major health risk." It said that if patients didn't have to see a doctor for a prescription, they might confuse asthma symptoms for allergy and endanger their health. But the FDA advisory committee, whose views the full agency usually follows, voted overwhelmingly to recommend that the full agency approve the switches. Author Affiliations: Alice C. Thornton, MD, is Assistant Professor of Medicine at the University of Kentucky and Project Director for the Bluegrass Care Clinic. Frank Romanelli, PharmD, is Assistant Professor of Pharmacy and a Clinical Specialist in HIV AIDS at the University of Kentucky. Jana D. Collins, BS, is the Data Coordinator for the Bluegrass Care Clinic and a graduate student in the Department of Family Studies. Her heart rate is now back down to a more normal 112 beats per minute.

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