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New drugs added since June 2002 indicated in bold. ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx ; , emtricitabine Emtriva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hydrea ; . Entry Inhibitor- enfuvirtide Fuzeon ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , fluconazole Diflucan ; , ganciclovir Cytovene ; , itraconazole Sporonox ; , leucovorin Wellcovorin ; , pyrimethamine Daraprim ; , sulfadiazine, TMP SMX Bactrim, Septra ; . Other OIs- albendazole Albenza ; , amoxicillin, amoxicillin culvulanate Augmentin ; , amphotericin B Fungizone ; , atovaquone Mepron ; , cephalexin Keflex ; , ciprofloxacin Cipro ; , clindanycin Cleocin ; , clotrimazole Lotrimin, Mycelex ; , dapsone, dicloxacillin, doxycycline Vibramycin ; , econazole Spectazole ; , erythromycin EES ; , erythromycin ethanol, erythomycin stearate, ethambutol Myambutol ; , gentamicin, ketoconazole Nizoral ; , levofloxacin Levaquin ; , metronidazole Flagyl , Metrogel ; , miconazole Micatin, Moniatat, Zeasorb-AF ; , nystatin Mycostatin ; , ofloxacin Ocuflox ; , paromonycin Humatin ; , penicillin V Potassium Vestids ; , pentamidine Nebupent, Pentam ; , primaquine, pyrazinamide, rifabutin Mycobutin ; , rifampin isonazid Rifadin, Rifamate ; , silver sulfadiazine Thermazene SSD ; , terconazole Terazol 7 ; , Tobramycin Sulfate, Valacyclovir Valtrex ; , Valganciclovir Valcyte ; . Hepatitis C- none. TREATMENTS FOR METABOLIC DISORDERS Hyperlipidemia- atrovostatin Lipitor ; , cholestyramine Questran ; , fenofibrate Tricor ; , fulvastatin Lescol ; , gemfibrozil Lopid ; , niacin Niaspan ; , pravastatin Pravachol ; , simvastatin Zocor ; .Wasting- dronabinol Marinol ; , megestrol acetate Megace ; . ALL OTHERS amitriptyline Elavil ; , amoxapine Ascendin ; , bacitracin, bacitracin polymyxinB, bacitracin Zinc, bupropion Wellbutrin ; , carbamazepine Tegretol ; , cefadroxil Duricef ; , cefazolin Ancef ; , chlor-hexidine Peridex ; , cimetidine Tagamet ; , citalopram Celexa ; , clomipramine Anafranil ; , colfazamine Lamprene ; , desipramine Norpramin, Petrofane ; , diphenoxylate HCI w Atropine Lomotil, Lonox ; , divalproex Depakote ; , doxepin Sinequan ; , fluoxetine Prozac ; , fluvoxamine Luvox ; , gabapentin Neurontin ; , Hydrocortisone various formulations ; , imipramine Tofranil ; , lamotrigine Lamictal ; , loperimide Imodium ; , magnesium sulfate, maprotiline Ludiomil ; , minocycline Minocin ; , mirtazapine Remeron ; , nefazodone Serzone ; , neomycin, nitrofurantoin Macrodantin ; , nortriptyline Aventyl, Pamelor ; , paroxetine Paxil ; , phenelzine Nardil ; , phenytoin Dilantin ; , prendisone, primidone Msyoline ; , probenecid, prochlorperazine Pyrazinamide ; , protriptyline Vivactil ; , rantitidine Zantac ; , sertraline Zoloft ; , tetracycline, tranylcypromine Pamate ; , trazodone Desyrel, Trialodine ; , trimipramine Surmontil ; , tobramycin, vancomycin, valporic acid Depkene ; , venlafxine Effexor.
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TM: Impaired pharmaceutical technician. Registration revoked. RA: Security violations pharmacist called in sick, could not find a replacement, store manager closed the pharmacy, and the pharmacy development manager allowed the assistant store manager and the key associate to enter the pharmacy and dispense filled prescriptions. , 500 fine , 401.52 costs and administrative fees. PF RA: Patient presented prescription for Mys9line 50 mg tablets for dispensing. Patient had two medications in his bag when he picked up prescription. After questioning, the pharmacist insisted the Celebrex was also patient's prescription. Both medications taken, and patient became dizzy, disoriented, and flushed. Celebrex was not the patient's medication the pharmacist did not clear computer screen and added the Celebrex prescription to the wrong patients' profile. Stipulated agreement accepted for , 000 fine, 0 administration fees for pharmacist and pharmacy. KB RA: Prescription for Provera and Premarin presented to pharmacy for bone density improvement. Both prescriptions were filled with Premarin. Patient ingested Premarin in 0.625 strength and 2.5 strength, which caused the 76year-old patient to bleed vaginally. , 000 fine for pharmacist and pharmacy. PS SP: Prescription for prednisone 20 mg tablets was misfilled with Prinivil. Patient took three tablets, blood pressure dropped to 78 41. Pharmacist fined 0. Pharmacy fined , 000 and 8.68 for cost of hearing. ml MW WM: Acutane prescription was refilled twice with no authorization for refills from physician. 0 fine, 0 administrative fees each. RA: Security violations pharmacist called in sick, could not find a replacement, store manager closed the pharmacy after taking all the will-call drugs to his office to dispense from there. , 000 fine for pharmacy. DD: Arrested at his place of employment for obtaining controlled substances for his personal use. License revoked. MJ AP: Prednisolone prescription for 11-month-old baby dispensed with wrong dose. The dosage was misinterpreted physician ordered `mg, ' technician read `ml, ' and overrode and oxytrol.
ITEM NUMBER 3025 3026 3027 CHARGE CODE 4211320 4211323 4211324 DESCRIPTION DILAUDID 4mg INJECTION MAGNESIUM CITRATE TRIDESILON CREAM 60GM LOXITANE 5mg CAPSULE UD THEO-DUR 50mg SPRINKLE MICRO K 10MEQ CAPSULE DEXTROSE 5% NACL .1% 1000M REGLAN 150mg 30ml INJ ALBUTEROL 2mg TABLET LIDO 1%-EPI 1: 100, 000 10ml MDV SORBITOL 70% 15ml DAKIN'S SOLUTION 1000ml DITROPAN SYRUP 5ml DOSE ASENDIN 100mg TABLET UD WATER STERILE 500ml ALCOHOL 15% DOSE MYLICON 80mg TABLET NIZORAL 200mg TABLET MEXITIL 200mg CAPSULE MAXZIDE TABLET UD GYNE-LOTRIMIN VAG TAB EACH LUDIOMIL 25mg TABLET CHLOROQUINE PO4 0.5GM TAB METUBINE IODINE 2mg CALAN 80mg TABLET TRACRIUM 10mg ml 10 ml AMP CERUBIDIN 20mg VIAL NAVANE 10mg IM DOSE SORBITOL 20% 100ml ZINC SULFATE 220mg CAP SODIUM CL .33% 1000ml LOTRISONE CREAM 45GM DURICEF SUSP 125mg 5ml 100ml MYSOLINE 250mg 5ml DOSE LIDEX GEL 0.05% 15GM CORTISONE ACETATE 25mg TAB GLYCINE IRRIGATE 3000ml PERCOCET-5 TABLET DECLOMYCIN 150 mg TABLET MENTHOL.15GM PETROLATUM30G SYNTHROID 0.05mg TABLET MAXIDEX OPHTH OINT 3.5GM ISORDIL 40mg MAXIDEX OPHTH SOLN 5ml METAPREL MIST REFILL INTRA-SITE GEL 15GM SHOLHS SOLUTION 15ml METAPREL MIST W ADPT INTRALIPID 10% 50ml MEDIHALER ISO REFILL 15ml WATER STERILE 1000ml DUO-MEDIHALER 15ml TONOCARD 400mg UD TABLET DOBUTAMINE 250mg INJECTION AFRIN PED NASAL DROP 20ml LOPID 300 mg CAPSULE Page 55 of 230 PRICE 4.31 2.58 30.95 DEPARTMENT PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY PHARMACY!
Lineages Davis et al., 1987; Weintraub et al., 1989; Choi et al., 1990; Boukamp et al., 1992 ; . For this reason, MyoD has been called a ``master regulatory gene'' for myogenesis Weintraub et al., 1989 ; . MyoD activates transcription of muscle-specific genes by associating with a member of a family of ubiquitous bHLH proteins, called E proteins Murre et al., 1989a, b; reviewed in Kadesch, 1992 ; , and binding to defined sequences, called E boxes, upstream from these genes Ephrussi et al., 1985; Church et al., 1985 ; . The fact that MyoD can convert most cell types to a myogenic phenotype suggests that no other tissue-specific proteins are required for MyoD activity Weintraub et al., 1989 ; . Rather, MyoD activity can be regulated by ubiquitous proteins, some of which may also function in growth control or in other differentiation processes. For example, expression of the ubiquitous transcription factor pRB, which plays a key role in regulation of the cell cycle, is required for MyoD activity Gu et al., 1993 ; . Furthermore, some tumors or tumor-derived cell lines, which exhibit uncontrolled growth and lose expression of their intrinsic differentiation program, are resistant to MyoD-induced differentiation Weintraub et al., 1989; Dias et al., 1992; Tapscott et al., 1993 ; . Finally, other tissue-specific bHLH proteins, such as SCL TAL and MASH, also heterodimerize with the same E pro and topamax.
Anderson, G., 315 Anderson, R., 252, 262 Andrade, C., 208 Andreasen, N., 23, 24 Andreski, P., 83 Anghelescu, I. 243 Anglin, M., 101 Angold, A. 264, 279 Angst, F., 152, 265, 266 Angst, J., 17, 18, 19, Ansoms, S., 107, 108, 109 Anticonvulsants. See Carbamazepine Tegretol Divalproex sodium Depakote Felbamate Felbatol Gabapentin Neurontin Lamotrigine Lamictal Levetiracetam Keppra Phenytoin Dilantin Primidone M7soline Tiagabine Gabatril Topiramate Topamax Zonisamide Zonegran ; Antidepressants, treating bipolar depression with see Bipolar depression, antidepressants ; Antiglucocorticoids, 201202 Anton, R., 117 Anttila, P., 109 Anxiety disorders and bipolar illness, 8586 Applebaum, J., 243 Arbaretaz, M., 88 Ardnt, S., 20 Arean, P., 315, 317 Aretaeus of Cappadocia, 11, 275 Arieti, S., 329 Aripiprazole Abilify ; , 150, 151, 156, Arndt, S., 95 Arnetz, B. B., 264 Arnold, L., 27, 138, 146 Arolt, V. 183 Aronson, M. D., 108, 109 Arrierio, J., 82 Arsenapine, 157 Artane. See Trihexyphenidyl Artane ; Artioli, P., 185 Arvilommi, P., 261 Aryal, S., 300 Asghar, S. A., 164 Ashton, C., 103 AstraZeneca, 156, 198 Ativan. See Lorazepam Ativan ; Atomoxetine Strattera ; , 69 Attention- Deficit Hyperactivity Disorder ADHD ; , 69, 84, 158. See also Child and adolescent bipolar disorder, and ADHD.
Micronase p p Minipress p Minocin Mirapex Moban Morphine Quantity limits apply. p Motrin MSIR Quantity limits apply. p p Mycelex p Mycolog II p Mysol9ne Namenda p Naprosyn Nardil Nasonex Quantity limits apply. p Navane Necon Neomycin p Neurontin Niaspan Nilandron Nitroglycerin p Nizoral p Nolvadex Nora-BE Norpace CR p Norpramin Norvasc Quantity limits apply. Nystatin p Ogen Ogestrel Omacor Omnicef One Touch Test Strips Quantity limits apply. Orinase p Ortho Evra Quantity limits apply. Ortho Tricyclen LO p Orudis OxyContin 160 mg Quantity limits apply; NOTE: for brand-name Oxycontin, only the 160 mg strength is preferred; for all other strengths, generic oxycodone is the preferred agent. Oxytrol Pamelor Pancrelipase Parlodel Parnate Paxil CR Pediazole Pegasys and atrovent.
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Precautions Possible Interactions: - Should be used with caution in patients with high blood pressure, seizures, acute anxiety disorders, and drug dependence. - Do not use if have taken monoamine oxidase MAO ; inhibitor such as isocarboxazid Marplan ; , phenelzine Nardil ; , or tranylcypromine Parnate ; in the last 14 days. - The following drugs may interact with methylphenidate: - warfarin Coumadin - phenytoin Dilantin - phenobarbital Luminal, Solfoton - primidone Mysloine - tricyclic antidepressants such as nortriptyline Pamelor ; , amitriptyline Elavil, Endep ; , doxepin Sinequan ; , desipramine Norpramin ; , clomipramine Anafranil ; , or imipramine Tofranil - selective serotonin reuptake inhibitors such as fluoxetine Prozac ; , fluvoxamine Luvox ; , paroxetine Paxil ; , or sertraline Zoloft - clonidine Catapres - guanethidine Ismelin ; - May cause drug dependence Side Effects: An irregular or fast heartbeat, chest pains or very high blood pressure blurred vision, severe headache, flushing ; , unusual behavior or confusion. If any of the above serious side effects occur, do not administer and seek emergency medical attention Minor side effects include insomnia difficulty sleeping ; , nervousness, drowsiness, dizziness, headache, blurred vision, tics repetitive movements ; , abdominal pain, nausea, or vomiting, decreased appetite or weight loss, or slower weight gain and or growth and combivent.
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Table 1. Tachycardia Origin and Results of Radiofrequency Catheter Ablation for Idiopathic Ventricular Arrhythmias.
POLICY 1. Services which are medically necessary for the diagnosis or treatment of disease, illness, or injury must meet accepted medical practice standards and be appropriate to the illness or injury for which it is performed as to type and intensity of service and setting of treatment. Ohio Admin. Code 5101: 3-1-01 A ; [2002]. ANALYSIS: Amerigroup testimony and appeal summary Exhibit A ; indicate that Amerigroup attempted to obtain a completed Medwatch form from the Appellant's treating physician, without success, with calls to that physician going unanswered. Amerigroup testimony further indicates that it is currently allowing the Appellant to receive the brand name version of Mysoline instead of the generic version that Amerigroup recommends. Testimony from the Appellant's father indicates that the generic version of Mysoline was given to the Appellant in 11-07, resulting in an increase of grand mal seizures for the Appellant, who had had fewer such seizures using the brand name version of that drug. Although Amerigroup attempts to secure a completed Medwatch form from the physician have been unsuccessful to date, such clinical information is still needed to correctly determine medical necessity for the brand name version of Mysoline. For the above reasons, the Prior Authorization denial of the brand name version of Mysoline cannot be affirmed. HEARING OFFICER'S RECOMMENDATION ISSUE 1381921 ; : The appeal should be SUSTAINED. Amerigroup should provide the Appellant's physician with another Medwatch form, with a copy of same to the Appellant, for completion by that physician and return to Amerigroup. Upon receipt of the Medwatch form and any other clinical information, Amerigroup should conduct a new review and provide notice to the Appellant, his authorized representative and his physician, affording appeal rights. FINAL ADMINISTRATIVE DECISION AND ORDER Page 2 of 5 and synthroid.
While clinical medicine addresses the needs of individual patient, public health provides a broad perspective in linking the disease's impacts and response to the society. For HIV.
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G. F. ASPREY AND PHYLLIS THORNTON PART I The use of local plants for medicinal remedies is a very prevalent practice in Jamaica. Among the poorer families, the morning meal frequently consists of nothing more than a cup of bush-tea prepared by steeping the leaves in hot water, with perhaps a small piece of bread or a little corn meal porridge. It is perhaps significant that the term breakfast is not used but 'taking' or `drinking' tea is substituted. Many of the plants used for treatment of colds and indigestion also provide the normal morning drinks. The large number of 'cold', 'fever' which includes malaria ; and 'indigestion' remedies is of some interest as providing a guide to the frequency of these complaints. The claims made for some of the plants may occasionally be justified by their chemical constituents. Some of them are, or have been, in the pharmacopoeias. On the other hand, in many cases the claims either have little justification or remain to be substantiated. Many of the doses used are of an unpleasant and even drastic nature. This may account for their popularity in view of the general impression that medicine must be unpleasant to be efficacious. The plants used as home remedies are frequently known only by their common names which may vary from district to district. Furthermore, different plants often have the same common name. This difficulty has been met by collecting specimens and determining their correct Latin name. By this means a useful reference herbarium of bush-tea plants is gradually being assembled in the Department of Botany of the University College of the West Indies. In addition to local information on the plants so far identified, reference has been made to the publications cited in the bibliography. Some attempt has been made to record usages in other areas of the Caribbean and in Africa as perhaps showing relationship with Jamaican practices. Upwards of one hundred and sixty species of plants distributed through sixty-two plant families will be dealt with in detail. The families Acanthaceae to Zygophyllaceae ; with the Latin names of the relevant species are arranged alphabetically. Common names .are included with that most frequently used, or that recommended for adoption by the authors, in bold type. Further work will, no doubt, add considerably to this list. In order to obviate constant repetition in the text of references to the literature, it has been decided to number the authors consecutively in the bibliography * . When an author has dealt with a particular plant from the medicinal or biochemical point of view, the corresponding number appears in parenthesis after the description of the plant. For purposes of easy reference, it is proposed to issue the following appendices: I. A list of the botanical names of Jamaican medicinal plants. Their names will be numbered consecutively and arranged in alphabetical order, irrespective of the family to which a plant belongs. The family and the common name or names will, however, be given under separate headings. II. A list of the common names of the Jamaican medicinal plants with cross reference to the botanical names. III. A list of 'complaints' arranged alphabetically with the botanical name of the plants known to be used as remedies. REFERENCE LIST OF MEDICINAL PLANTS IN JAMAICA ARRANGED IN ALPHABETICAL ORDER OF FAMILIES ACANTHACEAE A family of some two thousand herbaceous and woody species of warm regions but relatively few appear to have been analysed. Among them are many Javanese medicinal plants. Small amounts of alkaloids, the nature of which is not precisely known, occur and also bitter principles. The latter include andrographid, kalmeghin and rhinacanthin and diamox.
If the mysoline and phenobarb levels are too high, drowsiness, sleepiness, dizziness andunsteadiness of gait may occur.
The incidence of bowel obstruction [see 5: 4 Intestinal Obstruction] in pregnant patients ranges from one in 1, 500 to one in 66, 000.47 The most common cause of smallbowel obstruction during pregnancy is adhesions, which account for 55% of cases; volvulus accounts for 25% of cases, with hernia, cancer, and intussusception accounting for the remainder.48, 49 As the incidence of operative procedures and the average age of the mother at gestation have risen, the likelihood of adhesive obstruction has risen as well.This problem may be further exacerbated by the hypomotility or dysmotility known to occur during pregnancy.50 The need for laparotomy and lysis of adhesive bands during pregnancy is extremely low; however, when surgical management is necessary, fetal mortality is 26% and maternal mortality 5%. With intestinal obstruction, the main concern is to ensure that diagnosis is not delayed. Accordingly, any pregnant patient presenting with nausea, vomiting, and a history of abdominal surgery should be presumed to have a small-bowel obstruction until it is proved otherwise. Large-bowel obstruction is less common than small-bowel obstruction but can be seen more often as pregnancy progresses. The most common cause of large-bowel obstruction is cecal or sigmoid volvulus. Volvulus during pregnancy is associated with a 21% to 43% mortality.51 Colonic pseudo-obstruction, or Ogilvie syndrome, has also been reported late in pregnancy or in the early puerperium.52 Striking colonic dilatation without anatomic obstruction is apparent, with gas filling the entire length of the colon from cecum to rectum. The danger of cecal perforation is high when the maximum diameter of the cecum exceeds 12 cm. Management Any sign of bowel ischemia or perforation in a pregnant patient with intestinal obstruction should prompt immediate operation. For small-bowel obstruction, a nasogastric tube should be inserted, fluid resuscitation should be initiated, a Foley catheter should be placed, and a full battery of blood tests should be performed, including assessment of blood gas levels and electrolyte levels and a complete blood count. Because of the leukocytosis known to occur in pregnancy, close attention should be paid to the differential blood count. Any sign of increasing acute-phase activity may suggest ischemia or perforation. Evaluation of acid-base status may also be useful in assessing bowel viability. A flat-plate and an upright abdominal film can confirm the diagnosis of small-bowel obstruction and rule out free air.The risk of radiation exposure to the fetus must be weighed against the potential morbidity and mortality of a missed diagnosis. Once ischemia and perforation are ruled out, small-bowel obstruction should be treated with aggressive fluid resuscitation to ensure euvolemia and correction of electrolyte abnormalities. If and dulcolax.
30. The group of experts also thought it necessary to create a network of regional reference laboratories in Africa, Latin America, and Asia, with competence in these areas. To achieve this, the OIE programme envisages two preliminary activities: a ; Preparation of a list of existing resources, with the aid of an adapted questionnaire aimed at making an inventory of existing laboratories, together with their resources in terms of personnel and scientific equipment, and control methods that are already operational. This questionnaire has already been prepared. The creation of an evaluation team that shall examine the laboratory capabilities identified through responses to the questionnaire, and; prepare a list of urgent needs in terms of human, material, and methodological resources.
Migranal QL ; phenobarbital ergotamine bell Wigraine Other drugs: acetaminophen w butalbital butalbital compound w codeine Equagesic G ; Esgic Plus 500mg cap G ; Fioricet G ; Fiorinal w codeine No. 3 G ; Midrin G ; Sansert Stadol NS G ; Antianxiety and SedativeHypnotic Drugs Anxiolytics: alprazolam intensol Buspar G ; chlordiazepoxide HCl lorazepam oxazepam Sedative Hypnotic: Ambien QL ; estazolam flurazepam hydroxyzine HCl Restoril G ; triazolam Antimania Drugs lithium citrate Lithobid G ; Anticonvulsant Drugs Celontin clonazepam Depakene G ; Depakote Dilantin Dilantin Infatab ethosuximide Felbatol Gabitril Keppra Lamictal Mebaral Mesantoin Mysoline G ; Neurontin G ; Peganone phenobarbital Primidone Tegretol Tegretol XR Topamax Trilpetal Zarontin G ; Zonegran 100 mg Note: Zonegran 25 & 50mg have generics Antidepressant Drugs Amines: amitriptyline HCl amoxapine Anafranil G and ditropan and Order mysoline.
Were similar across the 3 treatment groups at baseline, although marginally fewer patients in the placebo group had undergone bypass surgery TABLE 1 ; . Two hundred sixty-nine patients were assigned to receive placebo, and 279 were assigned to receive 750 mg, and 275 to receive 1000 mg of ranolazine Figure 1 ; . Each medication dosage was prescribed to be taken twice a day.
1998; 361 1 ; : 151-15 review date: april 2002 reviewed by: participants in the review process include: ruth debusk, rd, phd, editor, nutrition in complementary care, tallahassee, fl; jacqueline hart, md, department of internal medicine, newton-wellesley hospital, harvard university and senior medical editor integrative medicine, boston, ma; gary kracoff, rph pediatric dosing section february 2001 ; , johnson drugs, natick, ma; steven ottariono, rph pediatric dosing section february 2001 ; , veteran's administrative hospital, londonderry, nh and arava.
New deposit and loan products, upgrade staff skills, improve loan recoveries, and profitability."ln the banking process, there are lots of redundantactivitieswhich have been going on for years. But most of them can be done general away with, " points out PradeepDas, 41, assistant manager, economic research and corporate planning, Vysya Bank. "Under TQM projects, we try and eliminate all such activities where value-additionis nil or very low." Then, a revisedprocessis prepared, which is presented to the TQM steering committee for its approval before it is taken up for implementation.On an average, Vysya Bank takes between 15 and 120 days to complete each TQM project. Last year, delaysin clearinginward bills - local and outstation cheques and drafts - was identified as the single-biggest customer complaint. A TQM project was initiated and the result is a new cheque clearing service that Vysya Bank soon plans to unveil. Called Vyswift, it will offer three options : 24-hour clearing, four-day clearing, and seven-day clearing, each camying a different charge. What the TQM team that developed Vyswift discoveredwas that outstation cheque clearances were taking upto 25 days becausethe bank's branchesdid not have a systemto follow. As the team went into the details, they discovered that the clearing delays were not only between the semi-urban branches.
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Elan received royalties and fees of 4, 524, 000 in 1999 compared with 9, 133, 000 in 1998, an increase of 23%. A significant proportion of licencing income is derived from collaborative arrangements where Elan may have an investment in the licencee. In all cases licence revenue is only recorded as income at such time as any obligation pursuant to the licence has been discharged. Elan's licence revenues are dependent on its ability to continue to source new licence business. Cost of sales increased by 45% from 5, 332, 000 for 1998 to 1, 184, 000 for 1999. The increase is 53% adjusting for exceptional items of , 397, 000 in 1998. The increase primarily reflects the increased sales volume and the inclusion in 1999 of a full years cost of sales arising from the acquisitions of Carnrick, Mysoline and other acquisitions in 1998. The gross margin, before exceptional items, decreased slightly from 79.6% for 1998 to 79.0% for the comparable period in 1999 reflecting the increase in product sales as a percentage of total sales thereby decreasing the overall margin. Gross margin on product sales increased from 59.7% in 1998 to 60.8% in 1999 reflecting the higher margin on sales of directly marketed products including Verelan, Mysoline and the Carnrick products, which were included for the full twelve months offset in part by lower margins on drug delivery products. Selling and distribution expenses for 1999 increased by 56% to 2, 624, 000 from 0, 989, 000 for 1998. The increase reflects the scale up of sales and marketing activities in the US, the building of our European infrastructure, the inclusion of the full twelve month numbers of Carnrick and Neurex Corporation "Neurex" ; and the cost of product launches. General and administrative expenses, after exceptional items, increased by 42% to , 308, 000 for 1999 from , 352, 000 for 1998. The increase, before exceptional items of , 707, 000 in 1998, is 81%. The increase reflects the inclusion of companies acquired during 1998 for the full year in 1999 and the general growth in the Company's activities. Research and development expenses, after exceptional items of , 181, 000 in 1998, increased by 58% from 5, 472, 000 for 1998 to 0, 172, 000 for 1999 reflecting a number of significant products in late stage development including ziconotide and Neurobloc and the inclusion of the full year costs for the 1998 company acquisitions including Nanosystems and Neurex. Share of profits losses ; of associates and joint ventures improved from a loss of , 256, 000 for 1998 to a profit of 2, 000 for 1999. The loss for 1998 primarily reflects Elan's share of losses in our joint venture with Emisphere Technologies, Inc. In 1999, Elan's share in the joint venture was acquired by Emisphere Technologies, Inc. The profit in 1999 represents Elan's share of profits and losses in our associates in Spain and Italy. Elan incurred exceptional charges during 1998 of 2, 569, 000 consisting of a charge of , 500, 000 related to a cash contribution to Axogen, a charge of , 747, 000 relating to the rationalisation and integration of acquisitions and a charge of , 322, 000 related to a loss on disposal of investments. Income from financial assets for 1999 increased by 163% to 2, 054, 000 from , 457, 000 for 1998 reflecting interest earned on significantly higher average cash and liquid resources in the current year following the 3.25% Zero Coupon Subordinated Exchangeable Notes "LYONs" ; offering in late 1998 and an increase in realised portfolio gains. Interest payable and other charges, increased by 252% to , 587, 000 for 1999 from , 178, 000 for the comparable period in 1998 primarily reflecting the inclusion for the full year of interest payable on the LYONs issued in December 1998, interest payable on the 8.43% Guaranteed Notes issued in June 1999 arising from the securitisation of certain investments and increased financing and other fees. Tax on profit on ordinary activities for 1999 increased by 88% to , 288, 000 from , 874, 000 for 1998. The effective tax rate of 2.1% in 1999 reflected tax at standard rates in the jurisdictions in which Elan operates, Irish patent derived income which is exempt from tax, tax at a 10% rate on Irish manufacturing operations, foreign withholding tax and the availability of loss carryforwards. Elan's Irish income was largely exempt from taxation pursuant to Irish legislation which exempts from Irish taxation income which is derived from qualifying patents. Currently, there is no termination date in effect for such exemption. Elan's manufacturing income was taxed at a rate of 10% in Ireland. This rate of taxation will be available to Elan until 31 December 2010. Basic earnings per share, after exceptional items, increased from ##TEXT##.62 for 1998 to .26 for 1999, an increase of 103%. Excluding 1998 exceptional items, earnings per share increased by 16%. Earnings per share growth is less than profit growth due to the dilutive effect of shares issued for acquisitions.
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